A Guide to Protease Inhibitor (PI) Boosting
Disclaimer: This section contains information on experimental dosages of saquinavir and ritonavir. Please refer to complete prescribing information.
CONTENTS OF THIS SECTION
Introduction
How are pharmacokinetics measured
How is antiviral efficacy measured
The concept of PI boosting
- How is PI boosting achieved?
- How does ritonavir increase exposure to the PIs?
- What is the effect of PI boosting?
- Is simultaneous dosing of ritonavir and PI required for optimal boosting?
- What dose of ritonavir is required for optimum boosting?
Safety considerations for PI boosting
- Use of ritonavir as part of a PI boosting regimen
- Increased exposure to the PI when boosted
- The impact of additional ritonavir on PI drug interactions
Double boosting strategies
Summary: key considerations when evaluating the use of ritonavir in a boosted regimen
